Faculty Summaries
Xiaowei Chen, PhD
Xiaowei Chen, PhD
Assistant Professor
Office Phone: 215-214-4288
Fax: 215-728-2741
Office: W363


    1. Pape-Zambito, D., Jiang, Z., Wu, H., Devarajan, K., Slater, C.M., Cai, K.Q., Patchefsky, A., Daly, M.B., and Chen, X. (2014). Identifying a highly-aggressive DCIS subgroup by studying intra-individual DCIS heterogeneity among invasive breast cancer patients. PLoS One 9, e100488.
    2. Chen, X., and Anderson, J.J. (2014). Diet and the bone marrow niche for stem cell recruitment. J Bone Miner Res 29, 1041-1042.
    3. Paliwal, A., Temkin, A.M., Kerkel, K., Yale, A., Yotova, I., Drost, N., Lax, S., Nhan-Chang, C.L., Powell, C., Borczuk, A., Aviv, A., Wapner, R., Chen, X., Nagy, P.L., Schork, N., Do, C., Torkamani, A., and Tycko, B. (2013). Comparative anatomy of chromosomal domains with imprinted and non-imprinted allele-specific DNA methylation. PLoS Genet 9, e1003622.
    4. Jiang, Z., Zhou, Y., Devarajan, K., Slater, C.M., Daly, M.B., and Chen, X. (2012). Identifying putative breast cancer-associated long intergenic non-coding RNA loci by high density SNP array analysis. Front Genet 3, 299.
    5. Gao, C., Devarajan, K., Zhou, Y., Slater, C.M., Daly, M.B., and Chen, X. (2012). Identifying breast cancer risk loci by global differential allele-specific expression (DASE) analysis in mammary epithelial transcriptome. BMC Genomics 13, 570.
    6. Brewster, B.L., Rossiello, F., French, J.D., Edwards, S.L., Wong, M., Wronski, A., Whiley, P., Waddell, N., Chen, X., Bove, B., Kconfab, Hopper, J.L., John, E.M., Andrulis, I., Daly, M., Volorio, S., Bernard, L., Peissel, B., Manoukian, S., Barile, M., Pizzamiglio, S., Verderio, P., Spurdle, A.B., Radice, P., Godwin, A.K., Southey, M.C., Brown, M.A., and Peterlongo, P. (2012). Identification of fifteen novel germline variants in the BRCA1 3'UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site. Hum Mutat 33, 1665-1675.
    7. Chen, X., Kistler, J.L., and Godwin, A.K. (2010). BRCA1-associated proteins: novel targets for breast cancer radiation therapy. In Aggressive Breast Cancer, R.H. DeFrina, ed. (Hauppauge, NY, Nova Science Publishers, Inc.), pp. 121-141.
    8. Chen, X., Weaver, J., Bove, B.A., Vanderveer, L.A., Weil, S.C., Miron, A., Daly, M.B., and Godwin, A.K. (2008). Allelic imbalance in BRCA1 and BRCA2 gene expression is associated with an increased breast cancer risk. Hum Mol Genet 17, 1336-1348.
    9. Chen, X., Truong, T.T., Weaver, J., Bove, B.A., Cattie, K., Armstrong, B.A., Daly, M.B., and Godwin, A.K. (2006). Intronic alterations in BRCA1 and BRCA2: effect on mRNA splicing fidelity and expression. Hum Mutat 27, 427-435.
    10. Chen, X., Arciero, C.A., Wang, C., Broccoli, D., and Godwin, A.K. (2006). BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation. Cancer Res 66, 5039-5046.
    11. Chen, X., Arciero, C.A., and Godwin, A.K. (2006). BRCA1-associated complexes: new targets to overcome breast cancer radiation resistance. Expert Rev Anticancer Ther 6, 187-196.
    12. Schilder, R.J., Sill, M.W., Chen, X., Darcy, K.M., Decesare, S.L., Lewandowski, G., Lee, R.B., Arciero, C.A., Wu, H., and Godwin, A.K. (2005). Phase II study of gefitinib in patients with relapsed or persistent ovarian or primary peritoneal carcinoma and evaluation of epidermal growth factor receptor mutations and immunohistochemical expression: a Gynecologic Oncology Group Study. Clin Cancer Res 11, 5539-5548.
    13. Guo, S., Hakimi, M.A., Baillat, D., Chen, X., Farber, M.J., Klein-Szanto, A.J., Cooch, N.S., Godwin, A.K., and Shiekhattar, R. (2005). Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Cancer Res 65, 3011-3016.
    14. Dong, Y., Hakimi, M.A., Chen, X., Kumaraswamy, E., Cooch, N.S., Godwin, A.K., and Shiekhattar, R. (2003). Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair. Mol Cell 12, 1087-1099.
    15. Chen, X., Garner, S.C., Quarles, L.D., and Anderson, J.J. (2003). Effects of genistein on expression of bone markers during MC3T3-E1 osteoblastic cell differentiation. J Nutr Biochem 14, 342-349.
    16. Chen, X.W., Garner, S.C., and Anderson, J.J. (2002). Isoflavones regulate interleukin-6 and osteoprotegerin synthesis during osteoblast cell differentiation via an estrogen-receptor-dependent pathway. Biochem Biophys Res Commun 295, 417-422.
    17. Chen, X., and Anderson, J.J.B. (2002). Effects of phytoestrogens on bone cells: genomic and nongenomic mechanisms. In Phytoestrogens and Health, G.S. Gilani, and J.J.B. Anderson, eds. (Champaign, IL, AOCS Press), pp. 248-259.
    18. Chen, X., and Anderson, J.J. (2002). Isoflavones and bone: animal and human evidence of efficacy. J Musculoskelet Neuronal Interact 2, 352-359.
    19. Anderson, J.J., Chen, X., Boass, A., Symons, M., Kohlmeier, M., Renner, J.B., and Garner, S.C. (2002). Soy isoflavones: no effects on bone mineral content and bone mineral density in healthy, menstruating young adult women after one year. J Am Coll Nutr 21, 388-393.
    20. Lee, Y.S., Chen, X., and Anderson, J.J.B. (2001). Physiological concentrations of genistein stimulate the proliferation and protect against free radical-induced oxidative damage of MC3T3-E1 osteoblast-like cells. Nutrition Res 21, 1287-1298.
    21. Chen, X., and Anderson, J.J. (2001). Isoflavones inhibit proliferation of ovarian cancer cells in vitro via an estrogen receptor-dependent pathway. Nutr Cancer 41, 165-171.
    22. Brayboy, J.R., Chen, X., Lee, Y.S., and Anderson, J.J.B. (2001). The protective effects of Ginkgo biloba extract (EGb 761) against free radical damage to osteoblast-like bone cells (MC3T3-E1) and the proliferative effects of EGb 761 on these cells. Nutrition Res 21, 1275-1285.