Faculty Summaries
Richard R Hardy, PhD
Richard R Hardy, PhD
  • Director,
Office Phone: 215-728-2469
Lab Phone: 215-728-2463
Fax: 215-728-2412

Recent Publications


  • Painter MW, Davis S, Hardy RR, Mathis D, Benoist C, Immunological Genome Project; Immunological Genome P. Transcriptomes of the B and T Lineages Compared by Multiplatform Microarray Profiling. J Immunol. 2011 Mar;186(5):3047-57.


  • Izumchenko E, Singh MK, Plotnikova OV, Tikhmyanova N, Little JL, Serebriiskii IG, Seo S, Kurokawa M, Egleston BL, Klein-Szanto A, Pugacheva EN, Hardy RR, Wolfson M, Connolly DC, Golemis EA. NEDD9 promotes oncogenic signaling in mammary tumor development. Cancer Res. 2009 Sep 15;69(18):7198-206.
  • Amin RH, Cado D, Nolla H, Huang D, Shinton SA, Zhou Y, Hardy RR, Schlissel MS. Biallelic, ubiquitous transcription from the distal germline Ig kappa locus promoter during B cell development. Proc Natl Acad Sci U S A. 2009 Jan;106(2):522-7.
  • Kadariya Y, Yin B, Tang BQ, Shinton SA, Quinlivan EP, Hua X, Klein-Szanto A, Al-Saleem TI, Bassing CH, Hardy RR, Kruger WD. Mice Heterozygous for Germ-line Mutations in Methylthioadenosine Phosphorylase (MTAP) Die Prematurely of T-Cell Lymphoma. Cancer Res. 2009 Jul;69(14):5961-9.
  • Zhang HB, Rosenberg S, Coffey FJ, He YW, Manser T, Hardy RR, Zhang JK. A Role for cFLIP in B Cell Proliferation and Stress MAPK Regulation. J Immunol. 2009 Jan;182(1):207-15.


  • Giambra V, Volpi S, Emelyanov AV, Pflugh D, Bothwell AL, Norio P, Fan Y, Ju Z, Skoultchi AI, Hardy RR, Frezza D, Birshtein BK. Pax5 and linker histone H1 coordinate DNA methylation and histone modifications in the 3' regulatory region of the immunoglobulin heavy chain locus. Mol Cell Biol. 2008;28:6123-6133.
  • Schram BR, Tze LE, Ramsey LB, Liu JB, Najera L, Vegoe AL, Hardy RR, Hippen KL, Farrar MA, Behrens TW. B cell receptor basal signaling regulates antigen-induced Ig light chain rearrangements. J Immunol. 2008 Apr;180(7):4728-41.


  • Balogh GA, Heulings R, Mailo D, Wang R, Li YS, Hardy R, Russo J. Methodological approach to study the genomic profile of the human breast. Int J Oncol. 2007 Aug;31(2):253-60.
  • Rowley B, Tang L, Shinton S, Hayakawa K, Hardy RR. Autoreactive B-1 B cells: Constraints on natural autoantibody B cell antigen receptors. J Autoimmun. 2007;29(4):236-45.
  • Kitaura Y, Jang IK, Wang Y, Han YC, Inazu T, Cadera EJ, Schlissel M, Hardy RR, Gu H. Control of the B cell-intrinsic tolerance programs by ubiquitin ligases cbl and Cbl-b. Immunity. 2007 May;26(5):567-78.
  • Anderson SJ, Lauritsen JP, Hartman MG, Foushee AM, Lefebvre JM, Shinton SA, Gerhardt B, Hardy RR, Oravecz T, Wiest DL. Ablation of ribosomal protein L22 selectively impairs alphabeta T cell development by activation of a p53-dependent checkpoint. Immunity. 2007;26:759-72.
  • Hardy RR, Kincade PW, Dorshkind K. The protean nature of cells in the B lymphocyte lineage. Immunity. 2007 Jun;26(6):703-14.


  • Hardy RR. B-1 B cell development. Brief reviews series. J Immunol. 2006;177:2749-54.
  • Hardy RR. B-1 B cell development, selection, natural autoantibody and leukemia. Current Opinion in Immunology. 2006;18:547-55.
  • Rumfelt LL, Zhou Y, Rowley BM, Shinton SA, Hardy RR. Lineage specification and plasticity in CD19- early B cell precursors. J Exp Med. 2006;203:675-87.


  • Wen L, Brill-Dashoff J, Shinton SA, Asano M, Hardy RR, Hayakawa K. Evidence of marginal zone B cell positive selection in spleen. Immunity. 2005;23:1-12.
  • Wen L, Shinton SA, Hardy RR, Hayakawa K. Association of B-1 B cells with follicular dendritic cells in spleen. J Immunol. 2005;174:6918-6926.
  • Hardy RR, Hayakawa K. Development of B cells producing natural autoantibodies to thymocytes and senescent erythrocytes. Springer Semin Immunopathol. 2005;26:363-75.
  • Tse LE, Lam K-P, Hogquist KA, Hippen KL, Liu J, Shinton SA, Rodine PR, Vegoe AL, Schlissel M, Hardy RR, Rajewsky K, Behrens TW. Basal immunoglobulin signaling activity maintains developmental stage in immature B cells. PLoS, 2005;3:e82.


  • Hardy RR, Wei C-J, Hayakawa K. Selection during development of VH11+ B cells: a model for natural autoantibody-producing CD5+ B cells. Immunol Rev. 2004;197:61-74.
  • Maier H, Ostraat R, Gao H, Fields S, Shinton SA, Medina KL, Ikawa T, Murre C, Singh H, Hardy RR, Hagman J. Early B cell factor cooperates with Runx1 and mediates epigenetic changes associated with mb-1 transcription. Nat Immunol. 2004;5:1069-1077.
  • Hardy RR. and Shinton SA. Characterization of B lymphopoiesis in mouse bone marrow and spleen. in "B Cell Protocols", Methods in Molecular Biology, Humana Press. 2004;271:1-24.


  • Hayakawa K, Asano M, Shinton SA, Gui M, Wen L-J, Dashoff J, Hardy RR. Positive selection of anti-Thy-1 autoreactive B-1 cells and natural serum autoantibody production independent from bone marrow B cell development. J Exp Med. 2003;197:87-99.
  • Hardy RR. Development of VH11+ B cells: a model for selection of B cells producing natural autoantibodies. Curr Dir Autoimmun. 2003;6:196-211.
  • Hardy RR. B-lymphocyte development and biology. in Fundamental Immunology (W.E. Paul, ed.), 5th ed. Lippincott Williams and Wilkins. 2003.
  • Hardy RR. B cell commitment: deciding on the players. Current Opinion in Immunology. 2003;15:258-65.


  • Bichi R, Shinton SA, Martin ES, Koval A, Calin GA, Cesari R, Russo G, Hardy RR, Croce CM. Human chronic lymphocytic leukemia modeled in mouse by targeted TCL1 expression. Proc Natl Acad Sci USA. 2002;99:6955-6960.


  • Allman D, Lindsley RC, DeMuth W, Rudd K, Shinton SA, Hardy RR. Resolution of three nonproliferative immature splenic B cell subsets reveals multiple selection points during peripheral B cell maturation. J Immunol. 2001;167:6834-6840.
  • Gui M, Li J, Wen L-J, Hardy RR, Hayakawa K. ?-chain influences but does not solely control autoreactivity of Va14J281T cells. J Immunol. 2001;167:6239-6246.
  • Hardy RR, Hayakawa K. B cell development pathways. Ann Rev Immunol. 2001;19:595-621.
  • Roederer M, Hardy RR. Frequency difference gating: a multivariate method for identifying subsets that differ between samples. Cytometry. 2001;45:56-64.