Faculty Summaries
Elizabeth Hopper-Borge, PhD
Elizabeth Hopper-Borge, PhD
Assistant Professor
Office Phone: 215-214-1505
Lab Phone: 215-214-3757
Fax: 215-728-3616
Office: W463
Research Interests
  • Determine the In Vivo role of Abcc10/ABCC10 in resistance
  • Physiological Role of ABCC10
  • Biochemistry of ABCC10
  • Development of an ABCC10 specific inhibitor
Description of research projects
Selected Publications

Fox Chase Programs

  1. Chen, Z-S, Hopper-Borge, E, Belinsky, MG, Shchaveleva, I, Kotova, E, Kruh, GD. Characterization of the transport properties of human multidrug resistance protein 7 (MRP7, ABCC10). Mol. Pharmacol. 63:351-358, 2003.
  2. Guo, Y, Kotova, E, Chen, Z-S, Lee, K, Hopper-Borge, E, Belinsky, MG, Kruh, GD. MRP8 (ABCC11) is a cyclic nucleotide efflux pump and a resistance factor for fluoropyrimidines, 23-dideoxycytidine and 9-(2-phosphonylmethoxyethyl)-adenine. J. Biol. Chem. 278: 29509-29514, 2003.
  3. Hopper-Borge, E, Chen, Z-S, Shchaveleva, I, Belinsky, MG, Kruh, GD. Analysis of the drug resistance profile of MRP7 (ABCC10): resistance to docetaxel. Cancer Res. 64:4927-4930, 2004.
  4. Risinger, AL, Jackson, EM, Polin, LA, Helms, GL, LeBoeuf, DA, Joe, PA, Hopper-Borge, E, Luduena, RF, Kruh, GD., Mooberry, SL. The taccolonides: microtubule stabilizers that circumvent clinically relevant taxane resistant mechanisms. Cancer Res. 68:8881-8888, 2008. PMC2727482
  5. Hopper-Borge, E, Xu, X, Shen, T, Shi, Z, Chen, ZS, Kruh, GD. Human multidrug resistance protein 7 (ABCC10) is a resistance factor for nucleoside analogues and epothilone B. Cancer Res. 69:178-184, 2009. PMC2745904
  6. Zhou, Y, Hopper-Borge, E, Shi, Z, Shen, T, Furukawa, T, Akiyama, S, Peng, XX, Huang, X.C., Ashby, C., Kruh, G.D., Chen, Z.S. Cepharanthine is a potent reversal agent for MRP7-mediated multidrug resistance. Biochem. Pharmacol. 77:993-1001, 2009. NIHMS84766
  7. Kuang, YH, Shen T, Chen X, Sodani K, Hopper-Borge E, Tiwari, AK, Lee JW, Fu LW, Chen, ZS. Lapatinib and erlotinib are potent reversal agents for MPR7 (ABCC10) mediated multidrug resistance. Biochem. Pharmacol. Jan 15;79(2):154-61, 2009.
  8. Shen, T, Kuang, Y., Ashby, CR, Lei, Y, Chen, A, Zhou, Y, Chen, X, Tiwari, AK, Hopper-Borge, E, Ouyang, J, Chen Z-S. Imatinib and nilotinib reverse multidrug resistance in cancer cells by inhibiting the efflux activity of the MRP7 (ABCC10). PLoS One 4(10):e7520, 2009. PMCID: PMC2759525
  9. Hopper-Borge, EA*, Churchill, T, Paulose C, Nicolas, E, Jacobs, JD, Ngo, O, Kuang, Y, Grinberg, Al, Westphal, H, Chen, ZS, Klein-Szanto, AJ, Belinsky, MG, Kruh, GD. Contribution of Abcc10 (Mrp7) to in vivo paclitaxel resistance as assessed in Abcc10-/- mice, Cancer Res. 2011;71(10):3649-3657. 2011 PMID:21576088This paper was selected by the Faculty of 1000 in 2011; http://f1000.com/7256956 * corresponding author
  10. Pushpakom, SP, Liptrott, N, Rodriguez-Novoa, S., Labarga, P, Soriano, V., Albalater, M, Hopper-Borge, E, Back, D., Khoo, S, Pirmohamed, M, Owen, A. Genetic variants of ABCC10, a novel tenofovir transporter are associated with kidney tubular dysfunction. Journal of Infectious Diseases, J Infect Dis. 2011 Jul; 204(1):145-53.
  11. Liptrott NJ, Pushpakom S, Wyen C, Fätkenheuer G, Hoffmann C, Mauss S, Knechten H, Brockmeyer NH, Hopper-Borge E, Siccardi M, Back DJ, Khoo SH, Pirmohamed M, Owen Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV/AIDs. Pharmacogenet Genomics. 2011 Nov 11.
  12. Malofeeva, EV, Domanitskaya, N, Gudima, M, and Hopper-Borge, E. Modulation of the ATPase and transport activities of broad specificity multidrug resistance factor ABCC10 (MRP7), Cancer Research, 2012 Dec 15;72(24):6457-67.Epub 2012 Oct. 19th. PMID:23087055
  13. Domanitskaya, N, Wangari-Talbot J, Jacobs J, Peiffer E, Mahdaviyeh Y, Paulose C, Malofeeva, E, Foster K, Cai KQ, Zhou Y, Egleston B, Hopper-Borge E. Abcc10 status affect mammary tumour growth, metastasis, and docetaxel treatment response.Br. J Cancer 2014 Aug 12;111(4):696-707 PMID:24937672
  14. Jacobs, J and Hopper-Borge, E, Carotid Artery Infusions for Pharmacokinetic and Pharmacodynamic Analysis of Taxanes in Mice. JOVE. 2014 Oct 27;(92): Issue 92; doi: 10.3791/51917 PMID:25407935
  15. Teijaro CN, Munagala S, Zhao S, Sirasani G, Kokkonda P, Malofeeva EV, Hopper-Borge E, Andrade RB. Synthesis and Biological Evaluation of Pentacyclic Strychnos Alkaloids as Selective Modulators of the ABCC10 (MRP7) Efflux Pump. J Med Chem. 2014 Dec 26;57(24):10383-90. doi: 10.1021/jm501189p. Epub 2014 Dec 8.PMID:25419978
All publications