Faculty Summaries
Richard A. Katz
Richard A. Katz, PhD
Research Professor
  • Adjunct Professor, 
Fels Institute for Cancer Research and Molecular Biology,
Temple University School of Medicine
Office Phone: 215-728-3668
Lab Phone: 215-728-3669
Fax: 215-728-2778
Office: R422

Epigenetic Regulation in Cancer and Normal Cells

  • The role of the nuclear lamina in epigenetic control.
  • High throughput siRNA screening to identify epigenetic silencing factor networks.
  • Epigenetic plasticity of melanoma cells.
  • Epigenetic silencing as an antiviral response.
  • Functional analyses of candidate breast cancer genes identified by Genome-wide Association Studies (GWAS) and Differential Allelic-Specific Expression (DASE).  
Description of research projects
Selected Publications

    My NCBI

  1. Peretz, Y., Wu, H., Patel, S., Bellacosa, A., Katz, R.A. Inhibitor of DNA Binding 4 (ID4) is highly expressed in human melanoma tissues and may function to restrict normal differentiation of melanoma cells. PLoS One 10:e0116839, 2015. PMCID: PMC4314081
  2. Poleshko, A., Kossenkov, A.V., Shalginskikh, N., Pecherskaya, A., Einarson, M.B., Skalka, A.M., Katz, R.A. Human factors and pathways essential for mediating epigenetic gene silencing. Epigenetics 9:1280-1289, 2014.  Selected for Cover Art.  PMCID: PMC4169020
  3. Poleshko, A., Katz, R.A. Specifying peripheral heterochromatin during nuclear lamina reassembly. Nucleus 5:32-39, 2014. PMCID: PMC4028353
  4. Poleshko, A., Mansfield, K.M., Burlingame, C.C., Andrake, M.D., Shah, N.R., Katz, R.A. The human protein PRR14 tethers heterochromatin to the nuclear lamina during interphase and mitotic exit. Cell Rep. 5:292-301, 2013. PMCID: PMC3867587
  5. Shalginskikh, N., Poleshko, A., Skalka, A.M., Katz, R.A. Retroviral DNA methylation and epigenetic repression are mediated by the antiviral host protein Daxx. J. Virol. 87:2137-2150, 2013.  Selected by the Editors as an "Article of Significant Interest".  PMCID: PMC3571491
  6. Poleshko, A., Shalginskikh, N., Katz, R.A.*  Functional networks of human epigenetic factors.  In: Epigenomics: From Chromatin Biology to Therapeutics (Appasani, K., ed.),  pp. 30-46.  Cambridge University Press, 2012.
  7. Poleshko, A., Einarson, M.B., Shalginskikh, N., Zhang, R., Adams, P.D., Skalka, A.M., Katz, R.A. Identification of a functional network of human epigenetic silencing factors. J. Biol. Chem. 285:422-433, 2010. PMCID: PMC2804189
  8. Frescas, D., Guardavaccaro, D., Kuchay, S.M., Kato, H., Poleshko, A., Basrur, V., Elenitoba-Johnson, K.S., Katz, R.A., Pagano, M. KDM2A represses transcription of centromeric satellite repeats and maintains the heterochromatic state. Cell Cycle 7:3539-3547, 2008. PMCID: PMC2636745
  9. Poleshko, A., Palagin, I., Zhang, R., Boimel, P., Castagna, C., Adams, P.D., Skalka, A.M., Katz, R.A. Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response. J. Virol. 82:2313-2323, 2008. PMCID: PMC2258957
  10. Katz, R.A., Jack-Scott, E., Narezkina, A., Palagin, I., Boimel, P., Kulkosky, J., Nicolas, E., Greger, J.G., Skalka, A.M. High-frequency epigenetic repression and silencing of retroviruses can be antagonized by histone deacetylase inhibitors and transcriptional activators, but uniform reactivation in cell clones is restricted by additional mechanisms. J. Virol. 81:2592-2604, 2007. PMCID: PMC1866008
  11. Greger, J.G., Katz, R.A., Ishov, A.M., Maul, G.G., Skalka, A.M. The cellular protein daxx interacts with avian sarcoma virus integrase and viral DNA to repress viral transcription. J. Virol. 79:4610-4618, 2005. PMCID: PMC1069566