Faculty Summaries
Beatrice Mintz, PhD
Beatrice Mintz, PhD
  • Jack Schultz Chair in Basic Science
Lab Phone: 15-728-2479
Fax: 215-728-3574


  • Mintz B, Silvers WK. "Intrinsic" immunological tolerance in allophenic mice (Reprinted from Science, vol 158, pg 1484-1487, 1967). J Immunol. 2007 Apr;178(7):4007-10.
  • Blelloch RH, Hochedlinger K, Yamada Y, Brennan C, Kim MJ, Mintz B, Chin L, Jaenisch R. Nuclear cloning of embryonal carcinoma cells. Proc Natl Acad Sci U S A. 2004 Sep 28;101(39):13985-90.
  • Milling SW, Sai T, Silvers WK, Mintz B. Inhibition of melanoma growth after treatment with dendritic cells in a Tyr-SV40E murine model requires CD4+ T cells but not CD8+ T cells. Melanoma Res. 2004 Dec;14(6):555-62.
  • Milling SW, Silvers WK, Sai T, Mintz B. Decline in MHC class I expression with increasing thickness of cutaneous melanomas in standard-strain transgenic mouse models. Melanoma Res. 2002 Jun;12(3):221-30.
  • Sai T, Milling SW, Mintz B. Freezing and thawing of bone marrow-derived murine dendritic cells with subsequent retention of immunophenotype and of antigen processing and presentation characteristics. J Immunol Methods. 2002 Jun 1;264(1-2):153-62.
  • Kelsall SR, Mintz B. Metastatic cutaneous melanoma promoted by ultraviolet radiation in mice with transgene-initiated low melanoma susceptibility. Cancer Res. 1998 Sep 15;58(18):4061-5.
  • Orlow SJ, Silvers WK, Zhou BK, Mintz B. Comparative decreases in tyrosinase, TRP-1, TRP-2, and Pmel 17/silver antigenic proteins from melanotic to amelanotic stages of syngeneic mouse cutaneous melanomas and metastases. Cancer Res. 1998 Apr 1;58(7):1521-3.
  • Silvers WK, Mintz B. Differences in latency and inducibility of mouse skin melanomas depending on the age and anatomic site of the skin. Cancer Res. 1998 Feb 15;58(4):630-2.
  • Kelsall SR, LeFur N, Mintz B. Qualitative and quantitative catalog of tyrosinase alternative transcripts in normal murine skin melanocytes as a basis for detecting melanoma-specific changes. Biochem Biophys Res Commun. 1997 Jul 9;236(1):173-7.
  • Le Fur N, Kelsall SR, Silvers WK, Mintz B. Selective increase in specific alternative splice variants of tyrosinase in murine melanomas: a projected basis for immunotherapy. Proc Natl Acad Sci U S A. 1997 May 13;94(10):5332-7.
  • Le Fur N, Silvers WK, Kelsall SR, Mintz B. Up-regulation of specific tyrosinase mRNAs in mouse melanomas with the c2j gene substituted for the wild-type tyrosinase allele: utilization in design of syngeneic immunotherapy models. Proc Natl Acad Sci U S A. 1997 Jul 8;94(14):7561-5.
  • LeFur N, Kelsall SR, Mintz B. Base substitution at different alternative splice donor sites of the tyrosinase gene in murine albinism. Genomics. 1996 Oct 15;37(2):245-8.
  • Mintz B, Silvers WK. Accelerated growth of melanomas after specific immune destruction of tumor stroma in a mouse model. Cancer Res. 1996 Feb 1;56(3):463-6.
  • Devries TJ, Kitson JL, Silvers WK, Mintz B. Expression of Plasminogen Activators and Plasminogen-Activator Inhibitors in Cutaneous Melanomas of Transgenic Melanoma- Susceptible Mice. Cancer Res. 1995 Oct 15;55(20):4681-7.
  • Orlow SJ, Hearing VJ, Sakai C, Urabe K, Zhou BK, Silvers WK, Mintz B. Changes in Expression of Putative Antigens Encoded by Pigment Genes in Mouse Melanomas at Different Stages of Malignant Progression. Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10152-6.
  • Kleinszanto AJ, Silvers WK, Mintz B. Ultraviolet Radiation-Induced Malignant Skin Melanoma in Melanoma-Susceptible Transgenic Mice. Cancer Res. 1994 Sep 1;54(17):4569-72.
  • Larue L, Dougherty N, Bradl M, Mintz B. Melanocyte Culture Lines from Tyr-Sv40e Transgenic Mice - Models for the Molecular Genetic Evolution of Malignant- Melanoma. Oncogene. 1993 Mar;8(3):523-31.
  • Mintz B, Silvers WK. Transgenic Mouse Model of Malignant Skin Melanoma. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8817-21.
  • Mintz B, Silvers WK, Kleinszanto AJ. Histopathogenesis of Malignant Skin Melanoma Induced in Genetically Susceptible Transgenic Mice. Proc Natl Acad Sci U S A. 1993 Oct 1;90(19):8822-6.
  • Larue L, Dougherty N, Mintz B. Genetic Predisposition of Transgenic Mouse Melanocytes to Melanoma Results in Malignant-Melanoma after Exposure to a Low Ultraviolet-B Intensity Nontumorigenic for Normal Melanocytes. Proc Natl Acad Sci U S A. 1992 Oct 15;89(20):9534-8.
  • Larue L, Dougherty N, Porter S, Mintz B. Spontaneous Malignant Transformation of Melanocytes Explanted from W(F)/W(F) Mice with a Kit Kinase-Domain Mutation. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7816-20.
  • Mintz B. Mosaic Expression of Mammalian Genes - Implications for Development and Neoplasia. Cytogenet Cell Genet. 1992;60(3-4):261.
  • Mintz B, Kleinszanto AJ. Malignancy of Eye Melanomas Originating in the Retinal-Pigment Epithelium of Transgenic Mice after Genetic Ablation of Choroidal Melanocytes. Proc Natl Acad Sci U S A. 1992 Dec 1;89(23):11421-5.
  • Bradl M, Klein-Szanto A, Porter S, Mintz B. Malignant melanoma in transgenic mice. Proc Natl Acad Sci U S A. 1991;88(1):164-8.
  • Bradl M, Larue L, Mintz B. Clonal Coat Color Variation Due to a Transforming Gene Expressed in Melanocytes of Transgenic Mice. Proc Natl Acad Sci U S A. 1991 Aug;88(15):6447-51.
  • Kleinszanto A, Bradl M, Porter S, Mintz B. Melanosis and Associated Tumors in Transgenic Mice. Proc Natl Acad Sci U S A. 1991 Jan;88(1):169-73.
  • Mintz B, Bradl M. Mosaic Expression of a Tyrosinase Fusion Gene in Albino Mice Yields a Heritable Striped Coat Color Pattern in Transgenic Homozygotes. Proc Natl Acad Sci U S A. 1991 Nov;88(21):9643-7.
  • Porter S, Larue L, Mintz B. Mosaicism of Tyrosinase-Locus Transcription and Chromatin Structure in Dark Vs Light Melanocyte Clones of Homozygous Chinchilla-Mottled Mice. Dev Genet. 1991;12(6):393-402.
  • Porter S, Mintz B. Multiple Alternatively Spliced Transcripts of the Mouse Tyrosinase-Encoding Gene. Gene. 1991 Jan 15;97(2):277-82.
  • Capel B, Hawley RG, Mintz B. Long-Lived and Short-Lived Murine Hematopoietic Stem-Cell Clones Individually Identified with Retroviral Integration Markers. Blood. 1990 Jun 15;75(12):2267-70.
  • Larue L, Mintz B. Pigmented Cell-Lines of Mouse Albino Melanocytes Containing a Tyrosinase Cdna with an Inducible Promoter. Somat Cell Mol Genet. 1990 Jul;16(4):361-8.