Faculty Summaries
Alana O'Reilly, PhD
Alana O'Reilly, PhD
Associate Professor
Office Phone: 215-214-1653
Lab Phone: 215-214-3219
Fax: 215-728-3574
Office: R343
Lab: R354

Nutritional mechanisms that influence stem cell function and development

  • Molecular mechanisms of Hedgehog signaling regulation by dietary cholesterol during development and in cancer.
  • Role of Hedgehog signaling in controlling epithelial stem cell lifetime.
  • Influence of dietary supplements on developmental events.
  • Development of a crowdsourcing model for cancer research in partnership with Philadelphia area high school students and teachers.
Description of research projects
Selected Publications

Fox Chase Programs


    My NCBI

  1. Hartman, T.R., Ventresca, E.*, Hopkins, A.*, Zinshteyn, D.E., Singh, T., O’Brien, J.A., Neubert, B.C., Hartman, M.G., Schofield, H.K., Stavrides, K.P., Talbot, D. E., Riggs, D. J., Pritchard, C., O’Reilly, A.M. Novel tools for genetic manipulation of Follicle Stem Cells in the Drosophila ovary reveal an integrin-dependent transition from quiescence to proliferation. Genetics, 114.173617. PubMed
  2. Strochlic TI, Stavrides KP, Thomas SV, Nicolas E, O'Reilly AM, Peterson JR. Ack kinase regulates CTP synthase filaments during Drosophila oogenesis. EMBO Rep. 11: 1184-91. 2014. PubMed
  3. Hartman TR, Strochlic TI, Ji Y, Zinshteyn, D, O’Reilly AM. Diet controls Drosophila follicle stem cell proliferation via Hedgehog sequestration and release. J Cell Biol. 2013;201:741-57.PubMed
  4. Hartman TM, Zinshteyn D, Schofield HK, Nicolas E, Okada A, O’Reilly AM. Drosophila Boi limits hedgehog levels to suppress follicle stem cell proliferation. J Cell Biol. 2010;191:943-952. PubMed
  5. O’Reilly AM, Lee H-H, Simon MA. Integrins control the positioning and proliferation of Follicle Stem Cells in the Drosophila ovary. J Cell Biol. 2008;182(4):801-815. Featured article and subject of Biobytes podcast, August 25, 2008. PubMed
  6. O’Reilly AM, Ballew AC, Miyazawa B, Stocker H, Hafen E, Simon MA. CSK differentially regulates Src64 during distinct morphological events in Drosophila germ cells. Development 2006;133:2627-2638. PubMed
  7. O’Reilly AM, Pluskey S, Shoelson SE, Neel BG. Activated mutants of SHP-2 preferentially induce elongation of Xenopus animal caps. Mol Cell Biol. 2000;20:299-311. PubMed
  8. O’Reilly AM, Neel BG. Structural determinants of SHP-2 function and specificity in Xenopus mesoderm induction. Mol Cell Biol. 1998;18:161-177. PubMed
  9. Van Vactor D, O’Reilly AM, Neel BG. Genetic analysis of protein tyrosine phosphatases. Curr Opin Genet Dev. 1998;8:112-126. PubMed