Faculty Summaries
Christoph Seeger, PhD
Christoph Seeger, PhD
Office Phone: 215-728-4312
Office: R212-216

Viral hepatitis

  • DNA repair enzymes involved in hepatitis B virus replication.
  • Development of CRISPR/Cas9 platforms for investigations on the HBV life cycle.
  • Use of CRISPR/Cas9 for genome-wide screens to identify drivers of drug resistance in liver cancer therapy.
Description of research projects
Selected Publications
    1. Cui, X., McAllister, R., Boregowda, R., Sohn, J.A., Ledesma, P., Caldecott, K.W., Seeger,C., Hu, J. Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair? PLoS ONE 10(6): e012840, 2015.
    3. Hu, J. and Seeger, C. Hepadnavirus genome replication and persistence. In: Hepatitis B and Delta Viruses (Seeger, C. and Locarnini, S., Eds.). pp 75-90, Cold Spring Harbor Laboratory Press. 2015.
    5. Seeger, C. and Mason, W.S. Molecular biology of hepatitis B virus infection. Virology 479-480:672, 2015.
    7. Seeger, C and Sohn J.A. Targeting HBV cccDNA with CRISPR/Cas9. Molecular Therapy-Nucleic Acids, e216; doi:10.1038/mtna.2014.68, 2014.
    9. Chisari F.V.,Mason, W.S., Seeger, C. Virology. Comment on “Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA”. Science 344:1237, 2014.
    11. Evans, J.D., Crown, R.A., Sohn, J.A., Seeger, C. West Nile Virus infection induces depletion of IFNAR1 protein levels. Viral Immunology 24:253-263, 2011.
    13. Sohn, J.A., Litwin, S., Seeger, C. Mechanism for CCC DNA synthesis in hepadnaviruses. PLoS ONE 4(11): e8093, 2009.