Faculty Summaries
Christoph Seeger, PhD
Christoph Seeger, PhD
Office Phone: 215-728-4312
Office: R212-216
Description of research projects
Selected Publications
  1. Cui X, McAllister R, Boregowda R, Sohn JA, Ledesma P, Caldecott KW, Seeger C, Hu J. Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair? PLoS ONE. 2015;10:e012840. PubMed
  2. Seeger C, Mason WS. Molecular biology of hepatitis B virus infection. Virology. 2015;479-480C:672-686. PubMed
  3. Hu J, Seeger C. Hepadnavirus genome replication and persistence. In: Hepatitis B and Delta Viruses (Seeger C, Locarnini S, Eds.). 2015. Cold Spring Harbor Laboratory Press.
  4. Seeger C, Sohn JA. Targeting HBV cccDNA with CRISPR/Cas9. Mol Ther Nucleic Acids. 2014;3:e216. PubMed
  5. Chisari FV, Mason WS, Seeger C. Virology. Comment on “Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA”. Science. 2014;344:1237. PubMed
  6. Seeger C, Zoulim F, Mason WS. Hepadnaviruses. In: Fields Virology 6th edition (Howley P, Knipe D, Eds.). 2013. Lippincott, Williams & Wilkins, NY, pp. 2185-2221
  7. Seeger C, Mason WS. Sodium-dependent taurocholic cotransporting polypeptide: a candidate receptor for human hepatitis B virus. Gut. 2013;62:1083-1095. PubMed
  8. Evans JD, Crown RA, Sohn JA, Seeger C. West Nile Virus infection induces depletion of IFNAR1 protein levels. Viral Immunol. 2011;24:253-263. PubMed
  9. Sohn JA, Litwin S, Seeger C. Mechanism for CCC DNA synthesis in hepadnaviruses. PLoS ONE. 2009;4:e8093. PubMed
  10. Stiffler JD, Nguyen M, Sohn JA, Liu C, Kaplan D, Seeger C. Focal distribution of hepatitis C virus RNA in infected livers. PLoS ONE. 2009;4:e6661. PubMed
  11. Evans JD, Seeger C. Differential effects of mutations in NS4B on West Nile virus replication and inhibition of interferon signaling. J Virol. 2007;81:11809-16. PubMed
  12. Guo JT, Hayashi J, Seeger C. West Nile virus inhibits the signal transduction pathway of alpha interferon. J Virol. 2005;79:1343-1350. PubMed
  13. Hayashi J, Stoyanova R, Seeger C. The transcriptome of HCV replicon expressing cell lines in the presence of alpha interferon. Virology. 2005;335:264-75. PubMed
  14. Guo JT, Zhu Q, Seeger C. Cytopathic and noncytopathic interferon responses in cells expressing hepatitis C virus subgenomic replicons. J Virol. 2003;77:10769-79. PubMed
  15. Zhu Q, Guo JT, Seeger C. Replication of hepatitis C virus subgenomes in nonhepatic epithelial and mouse hepatoma cells. J Virol. 2003;77:9204-10. PubMed
All publications