Faculty Summaries
Christoph Seeger, PhD
Christoph Seeger, PhD
Office Phone: 215-728-4312
Office: R212-216

2000 - Present

  • Cui X, McAllister R, Boregowda R, Sohn JA, Ledesma P, Caldecott KW, Seeger C, Hu J. Does tyrosyl DNA phosphodiesterase-2 play a role in hepatitis B virus genome repair? PLoS ONE. 2015;10:e012840. PubMed
  • Seeger C, Mason WS. Molecular biology of hepatitis B virus infection. Virology. 2015;479-480C:672-686. PubMed
  • Hu J, Seeger C. Hepadnavirus genome replication and persistence. In: Hepatitis B and Delta Viruses (Seeger C, Locarnini S, Eds.). 2015. Cold Spring Harbor Laboratory Press.
  • Seeger C, Sohn JA. Targeting HBV cccDNA with CRISPR/Cas9. Mol Ther Nucleic Acids. 2014;3:e216. PubMed
  • Chisari FV, Mason WS, Seeger C. Virology. Comment on “Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA”. Science. 2014;344:1237. PubMed
  • Seeger C, Zoulim F, Mason WS. Hepadnaviruses. In: Fields Virology 6th edition (Howley P, Knipe D, Eds.). 2013. Lippincott, Williams & Wilkins, NY, pp. 2185-2221
  • Seeger C, Mason WS. Sodium-dependent taurocholic cotransporting polypeptide: a candidate receptor for human hepatitis B virus. Gut. 2013;62:1083-1095. PubMed
  • Evans JD, Crown RA, Sohn JA, Seeger C. West Nile Virus infection induces depletion of IFNAR1 protein levels. Viral Immunol. 2011;24:253-263.
  • Seeger C, Lai MM, Mason WS. Molecular Biology of Hepatitis Viruses. In: The Liver, Biology and Pathobiology, 4th edition, Lippincott, Williams Wilkins, NY. Forthcoming 2009.
  • Sohn JA, Litwin S, Seeger C. Mechanism for CCC DNA synthesis in hepadnaviruses. PLoS ONE. 2009;4:e8093.
  • Stiffler JD, Nguyen M, Sohn JA, Liu C, Kaplan D, Seeger C. Focal distribution of hepatitis C virus RNA in infected livers. PLoS ONE. 2009;4:e6661.
  • Evans JD,Seeger C. Innate Immune Response against West Nile virus. In: West Nile Encephalitis Virus Infections (Diamond, M. Ed.). 2008. Springer, pp. 155-168.
  • Seeger C, Evans JD. Differential effects of mutations in NS4B on West Nile virus replication and inhibition of interferon signaling. J Virol. 2007;81:11809-11816.
  • Seeger C, Zoulim F, Mason WS. Hepadnaviruses. In: Fields Virology (Howley P, and Knipe D, Eds). 2007. Lippincott, pp. 2977-3029.
  • Seeger C, Mason, WS. Replication of hepadnaviruses. In: DNA Replication in Eukaryotic Cells (dePamphilis, E., Ed.), Cold Spring Harbor Laboratory Press, Cold Spring Harbor. 2006 pp. 729-744.
  • Evans J, Seeger C. Cardif: a protein central to innate immunity is a target for the hepatitis C virus NS3 protease. Hepatology. 2006;43:615-617.
  • Seeger, C. Salient molecular features of hepatitis C virus revealed. Trends Microbiol. 2005;13:528-534.
  • Hayashi J, Stoyanova R, Seeger C. The transcriptome of HCV replicon expressing cell lines in the presence of alpha interferon. Virology. 2005;335:264-275.
  • Guo J-T, Hayashi J, Seeger C. West Nile virus inhibits the signal transduction pathway of Interferon alpha. J Virol. 2005;79:1343-1350.
  • Narezkina A, Taganov KD, Litwin S, Stoyanova R, Hayashi J, Seeger C, Skalka AM, Katz RA. Genome-wide analyses of avian sarcoma virus integration sites. J Virol. 2004;78:11656-11663.
  • Zhu Y, Cullen JM, Aldrich CE, Saputelli J, Miller D, Seeger C, Mason WS, Jilbert AR. Adenovirus-based gene therapy during clevudine treatment of woodchucks chronically infected with woodchuck hepatitis virus. Virology. 2004;327:26-40.
  • Guo J-T, Sohn JA, Zhu Q, Seeger C. Mechanism of the IFN-α response against hepatitis C virus replicons. Virology. 2004;325:71-81.
  • Seeger C, Zhu Q, Guo J-T. Characterization of the IFN-α response against HCV in hepatoma cells. In Therapy for viral hepatitis and prevention of hepatocellular carcinoma, M. Omata and K. Okita (Eds.), pp. 123-132, Springer, 2004.
  • Guo J-T, Zhu Q, Seeger C. Cytopathic and noncytopathic interferon responses in cells expressing hepatitis C virus subgenomic replicons. J Virol. 2003;77:10769-10779.
  • Zhu Q, Guo J-T, Seeger C. Replication of hepatitis C virus subgenomes in nonhepatic epithelial and mouse hepatoma cells. J Virol. 2003;77:9204-9210.
  • Guo J-T, Pryce M, Wang X, Barrasa MI, Hu J, Seeger C. Conditional replication of duck hepatitis B virus in hepatoma cells. J Virol. 2003;76:1885-1893.
  • Guo J-T, Bichko VV, Seeger C. Effect of alpha interferon on the hepatitis C virus replicon. J Virol. 2001;75:8516-8523.
  • Barrasa MI, Guo J-T, Saputelli J, Mason WS, Seeger C. Does a cdc2 kinase-like recognition motif on the core protein of hepadnaviruses regulate assembly and disintegration of capsids? J Virol. 2001;75:2024-2028.
  • Zhou T, Guo J-T, Nunes FA, Molnar-Kimber KL, Wilson JM, Aldrich CE, Saputelli J, Litwin S, Condreay LD, Seeger C, Mason WS. Combination therapy with lamivudine and adenovirus causes transient suppression of chronic woodchuck hepatitis virus infections. J Virol. 2000;74:11754-11763.
  • Seeger C, Mason WS. Hepatitis B Virus Biology. Microbiol Mol Biol Rev. 2000;64:51-68.
  • Guo J-T, Zhou H, Liu C, Aldrich C, Saputelli J, Whitaker RA, Barrasa MI, Mason WS, Seeger C. Apoptosis and regeneration of hepatocytes during recovery from transient hepadnavirus infection. J Virol. 2000;74:1495-1505.

1990 - 1999

  • Seeger C, Mason WS. Chronic hepadnavirus infections of the woodchuck and duck. In: Persistent Viral Infections (Ahmed R. and Chen I, Eds.), 1999, pp. 607-621. John Wiley & Sons, Ltd.
  • Seeger C, Mason W. Replication of the hepatitis B virus genome. In: Hepatitis B Virus: Molecular Mechanism in Disease and Novel Strategies for Therapy (Koshy R, and Caselmann WH, Eds.), 1998, pp. 1-20. Imperial College Press, London.
  • Hu J, Seeger C. RNA signals that control DNA replication in hepadnaviruses. Semin Virol. 1998;8:5502-511.
  • vSeeger C, Hu J. Why are hepadnaviruses DNA and not RNA viruses? Trends Microbiol. 1997;5:447-450.
  • Ladner SK, Otto MJ, Barker CS, Zaifert K, Wang GH, Guo JT, Seeger C, King RW. Inducible expression of human hepatitis B virus (HBV) in stably transfected hepatoblastoma cells: a novel system for screening potential inhibitors of HBV replication. Antimicrobial Agents Chemother. 1997;41:1715-1720.
  • Seeger C. The hepatitis B virus X protein: The quest for a role in viral replication and pathogenesis. Hepatology. 1997;25:496-498.
  • Hu J, Seeger C. Hepadnavirus assembly and reverse transcription require a multi-component chaperone complex which is incorporated into nucleocapsids. EMBO J. 1997;16:59-68.
  • Hu J, Seeger C. Expression and characterization of the hepadnavirus reverse transcriptase. In: Viral Polymerases and Related Proteins, Methods in Enzymology (Kuo LC, Olson DB, and Carroll SS, Eds.), 1996, Vol. 275, pp 195-208. Academic Press Inc, Orlando.
  • Seeger C, Leber EH, Wiens LK, Hu J. Mutagenesis of a hepatitis B virus reverse transcriptase yields temperature sensitive virus. Virology. 1996;222:430-439.
  • Seeger C, Mason W. Replication of the hepatitis virus genome. In: DNA Replication in Eukaryotic Cells (dePamphilis E, Ed.), 1996, pp. 815-832. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
  • Hu J, Seeger C. Hsp90 is required for the activity of a hepatitis B virus reverse transcriptase. Proc Natl Acad Sci USA. 1996;93:1060-1064.
  • Zoulim F, Seeger C, Trepo C. Experimental models for hepadnaviruses and antiviral strategies. Gastroenterol Clin Biol. 1995;19:161-171.
  • Seeger C. Hepatitis B virus: Molecular biology. In: Encyclopedia of Virology (Webster RB and Garnoff A, Eds.), 1995, pp. 560-564. Academic Press, Ltd., London.
  • Wang G-H, Zoulim F, Leber E, Kitson J, Seeger C. Role of RNA in enzymatic activity of the reverse transcriptase of hepatitis B viruses. J Virol. 1994;68:8437-8442.
  • Zoulim F, Wang G-H, Seeger C. Methods for the purification of enzymatically active reverse transcriptase of duck hepatitis B virus. In: Viral Hepatitis and Liver Disease (Nishioka K, et al, Eds.), 1994, pp. 97-100. Springer-Verlag, New York.
  • Seeger C. The reverse transcriptase of hepatitis B virus. Intl Antiviral News. 1994;2:100.
  • Zoulim F, Seeger C. Woodchuck hepatitis virus X gene is required for viral infection in vivo. J Virol. 1994;68:2026-2030.
  • Zoulim F, Seeger C. Reverse transcription in hepatitis B viruses is primed by a tyrosine residue of the polymerase. J Virol. 1994 68:6-13.
  • Wang G-H, Seeger C. A novel mechanism for reverse transcription in hepatitis viruses. J Virol. 1993;67:6507-6512.
  • Hansen L, Seeger C, Tennant BC, Ganem D. Differential activation of myc gene family members in hepatic carcinogenesis by closely related hepatitis B viruses. Mol Cell Biol. 1993;13:659-667.
  • Wang G-H, Seeger C. The reverse transcriptase of hepatitis B virus acts as a protein-primer for viral DNA synthesis. Cell. 1992;71:663-670.
  • Condreay LD, Wu T-T, Aldrich CE, Delaney MA, Summers J, Seeger C, Mason WS. Replication of DHBV genomes with mutations at the sites of initiation of minus- and plus-strand DNA synthesis. Virology. 1992;188:208-216.
  • Seeger C, Summers J, Mason WS. Viral DNA synthesis. In: Hepadnaviruses: Biology and Pathogenesis, Current Topics in Microbiology and Immunology (Mason WS, and Seeger C, Eds.), 1991. Vol. 168, pp. 41-59.
  • Seeger C. Hepadnavirus replication. In: Molecular Biology of the Hepatitis B Virus (McLachlan A, Ed.), 1991. pp. 213-226. CRC Press.
  • Seeger C, Maragos J. Identification of a signal necessary for initiation of reverse transcription of the hepadnavirus genome. J Virol. 1991;65:5190-5195.
  • Seeger C, Baldwin B, Hornbuckle WH, Yeager A, Tennant BC, Cote P, Ferrel L, Ganem D, Varmus HE. Woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus. J Virol. 1991;65:1673-1679.
  • Seeger C, Maragos J. Identification and characterization of the woodchuck hepatitis virus origin of DNA replication. J Virol. 1990;64:16-23.

1980 - 1989

  • Seeger C, Baldwin B, Tennant BC. Expression of infectious woodchuck hepatitis virus in murine and avian fibroblasts. J Virol. 1989;63:4665-4669.
  • Aldrich CE, Coates L, Wu T-T, Newbold J, Tennant BC, Summers J, Seeger C, Mason WS. In vitro infection of woodchuck hepatocytes with woodchuck hepatitis virus and ground squirrel hepatitis virus. Virology. 1989;172:247-252.
  • Seeger C, Maragos J. Molecular analysis of the function of direct repeats and a polypurine tract for plus strand DNA priming in woodchuck hepatitis virus. J Virol. 1989;63:1907 1915.
  • Seeger C, Marion P, Ganem D, Varmus HE. In vitro recombinants of ground squirrel and woodchuck hepatitis viral DNA produce infectious virus in squirrels. J Virol. 1987;61:3241-3247.
  • Seeger C, Ganem D, Varmus HE. Genetic analysis of hepadnaviruses. In: Viral Infections (Marget W, Lang W, and Gabler Sandberger E, Eds.) 1986. Vol. 1, pp. 92 96. MMV, Munich.
  • Seeger C, Ganem D, Varmus HE. Biochemical and genetic evidence for the hepatitis B virus replication strategy. Science. 1986;232:477 487.
  • Seeger C, Ganem D, Varmus HE. The cloned genome of ground squirrel hepatitis virus is infectious in the animal. Proc Natl Acad Sci USA. 1984;81:5849 5852.
  • Seeger C, Ganem D, Varmus HE. The nucleotide sequence of an infectious, molecularly cloned genome of ground squirrel hepatitis virus. J Virol. 1984;51:367 375.
  • Weiser B, Ganem D, Seeger C, Varmus HE. Closed circular viral DNA and asymmetric heterogeneous forms in livers from animals infected with ground squirrel hepatitis virus. J Virol. 1983;48:1 9.